Wet Granulator Machine

A wet granulation machine is a machine that mixes powder with a liquid binder to form uniform and dense granules for easier processing.

Wet Granulator for Capsule and Tablet Manufacturing

The wet granulator is also called a wet granulation machine. It plays a key role in pharmaceutical and nutraceutical production. The granulation equipment converts powders into uniform and compressible granules with a liquid binder. Granules feature consistent size and density, ideal for tablet compression or capsule filling. When materials are difficult to process, like poor flow or compressibility, this method is useful to improve these features for smooth processing.

Different granulators support various wet granulation methods. Some use mesh and rollers to complete the granulating. The production capacity could be up to 300 kg/h with 12 mesh. Some are equipped with mixing and cutting blades. The granulating batch could be within 7-10 minutes.

Types of Wet Granulation Machine

Vibrating Granulator CYK Series

Vibrating Granulator CYK Series

Get consistent granule size with the CYK series wet granulators—durable, stainless steel, and easy to maintain.

Wet Mixing Granulator CHL Series

Wet Mixing Granulator CHL Series

From small lab use to full production, CHL-W machines support various materials with adjustable mixing and cutting speeds.

Why Choose Anxine Wet Granulators?

High efficient production

Flexible capacity to meet different production needs.

Excellent granule quality

Uniform granules with good flowability, and stable tablet weight.

User-friendly design

Supports quick installation and disassembly, with safety interlock features.

Wide application

They could be used in the pharma, food, and chemical areas for different uses.

Applications & Industries

Wet granulation machines are widely used in the pharma, food, or nutritional industries. They have different functions to meet user demands.

Taste-masked granules

Used for bitter or irritating ingredients such as herbal extracts and minerals.

Effervescent Products

Vitamins, functional drinks, and cleaning products.

Controlled-release Granules

Used in pharmaceutical and functional supplements that require long-lasting and stable release.

Instant Soluble Products

Instant powders such as drink mixes, protein powders, and electrolyte powders.

How Does a Wet Granulator Work?

There are three main wet granulation methods in production, including high shear, fluid bed and extrusive wet granulation. They differ in how granules are formed and controlled. Here, we introduce how extrusive wet granulation works.

Powder loading

Powder materials are fed into the mixing chamber.

Mixing

The powders are mixed for even distribution of all ingredients.

Adding Binder.

A liquid binder is sprayed or poured into the powder while mixing continues.

Wet Mass Formation

The mixture becomes a moist mass as particles stick together.

Granule Formation

The wet mass is passed through a screen or processed by an impeller to form granules of a required size.

Discharge

The wet granules are discharged and sent for drying and further processing.

How to Select a Wet Granulator to Avoid Clumps?

Material properties are a key factor in influencing the granule quality. If ignoring them, it may lead to problems like lump formation or uneven granules. The common reasons why granules get clumped are always as follows.

Poor Flowability

It can lead to uneven mixing and local over-wetting, which may cause lump formation.

Sensitivity to Moisture

These powders become sticky quickly when liquid is added or turn into a paste.

Unsuitable Binder Type

If the binder is too strong or the liquid is added unevenly, it can result in uneven granule size or lump formation.

Other Related Elements

Spray rate, mixing speed, and batch size also influence the granulation result.

Comparison & Specifications

Anxine offers two types of wet granulation equipment: CHL series and CYK series. They feature different granulation methods and parameters.

Model CHL series CYK series
Method High-shear wet granulation Roller pressing + screen extrusion
Granule features Dense granules with adjustable size Uniform granules, shape determined by screen mesh.
Production  Batch type, 7-10 m/ batch Continuous type, 20-300 kg/h
Adjustment Many parameters could be adjusted, such as mixing speed, cutting speed, interval. Fixed roller speed 46 r/min, and granule size is defined by screen mesh & roller pressure.
Power Mixing motor: 4-16 kW; cutting motor: 1.3-5.5 kW 0.55-5.5 kW
Advantages Precise granule control, consistent quality, good for multi‑formula testing. Simple structure, high continuous output, low powder content.
Disadvantages More complex, higher price and maintenance costs. Lower precision in granule control, limited formula adjustment flexibility.

Compatible Upstream & Downstream Machines

For continuous and efficient production, many manufacturers integrate wet granulators with other processing equipment to make a production line.

Powder Grinder Machine

Powder Grinder Machine

A powder grinder is a machine that crushes solid materials into fine powder for use in industries such as pharmaceutical, food, and chemical production.

Industrial Powder Blender

Industrial Powder Blender

Powder blenders achieve fast, uniform mixing of materials across batches and are widely used in the pharmaceutical, food, and chemical industries.

Capsule Filling Machine

Capsule Filling Machine

Capsule filler machine​s are used to efficiently fill empty capsules with precise amounts of powders, granules, pellets or liquid in pharmaceutical and supplement production.

Blister Packaging Machine

Blister Packaging Machine

Engineered for pharmaceutical and nutraceutical production, this equipment reliably forms and seals Alu-PVC and Alu-Alu packs for tablets, capsules, and softgels.

Cartoning Machine

Cartoning Machine

We offer China cartoning machines for pharmaceuticals, food, and cosmetics. Our carton machines deliver high performance to meet global packaging needs.

FAQs on Wet Granulators

Know more about wet granulation equipment and get a clear understanding.

It can process powders such as pharmaceutical ingredients, food powders, herbal extracts, and some chemical materials.
Batch granulation processes materials in fixed amounts, while continuous granulation runs non-stop. The latter is more suitable for large-scale production.
Granule quality depends on material properties, binder type, machine design, and process settings such as mixing speed and liquid addition.
Anxine wet granulators use stainless steel construction and easy-clean structures to keep GMP compliance.
The best binder depends on the material and product requirements. Common options include PVP, HPMC, and starch. It is selected based on desired granule strength and dissolution.
Yes, many manufacturers offer customization based on material type, production capacity, and factory layout, including feeding systems and control options.
Anxine offers installation guidance, operation training, spare parts supply, and technical support if you need.

Wet Granulator Resources

Find more useful articles about wet granulation and related production.

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We Offer

Explore cutting-edge pharmaceutical and packaging machinery with Anxine. Supported by expert custom solutions and a robust global service network.

Capsule Filling Machine

Capsule filler machine​s are used to efficiently fill empty capsules with precise amounts of powders, granules, pellets or liquid in pharmaceutical and supplement production.

Tablet Press Machine

Tablet press machine is a specialized machine for producing tablets and pills.

Softgel Encapsulation Machine

A softgel encapsulation machine is designed to fill and seal liquid or semi-liquid materials into soft gelatin capsules.

Gummy Making Machine

Gummies making machines are automated systems used to produce gummy candies and supplements for the confectionery and pharmaceutical industries.

Industrial Powder Blender

Powder blenders achieve fast, uniform mixing of materials across batches and are widely used in the pharmaceutical, food, and chemical industries.

Pill Counting Machine

Engineered to rapidly and accurately count tablets, capsules, and gummies. Automate your pharmaceutical packaging process with diverse solid dosage counting solutions.

Blister Packaging Machine

Engineered for pharmaceutical and nutraceutical production, this equipment reliably forms and seals Alu-PVC and Alu-Alu packs for tablets, capsules, and softgels.

Cartoning Machine

We offer China cartoning machines for pharmaceuticals, food, and cosmetics. Our carton machines deliver high performance to meet global packaging needs.

Pouch Packing Machine

Automated pouch filling and sealing systems. Precisely dose powders, granules, liquids, and solids to streamline your pharmaceutical, nutraceutical, and food packaging lines.

Liquid Filling Machine

Precision equipment engineered to accurately dispense liquids, pastes, creams, and gels for efficient pharmaceutical, cosmetic, and chemical production lines.

Empty Capsules

We provide a variety of capsule shells in different sizes and materials for diverse formulations and target groups. They are suitable for the pharmaceutical, nutritional supplement, and functional food industries. We offer immediate-release, enteric-coated, and sustained-release solutions.

TiO₂-Free Capsules

Switch to our TiO₂-free capsules for safer, more reliable protection of your products.

Get in touch with us

Anxine


info@anxine.com
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+86-137-5776-3288
Anxine Machinery Co., Ltd
Zhejiang, China (GMT+08)

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